One of the more ominous articles of recent weeks came from WIRED magazine in an article about the proliferation of DNA editing. The story is rich with technical talk and it gets bogged down in places but essentially it is about a group of scientists who are concerned about the Pandora’s Box they may have created with something called Crispr-Cas9, or Crispr for short. Foreseeing this as far back as 1975, the group thought that establishing “guidelines” for what biologists could and could not do; things like creating pathogens and mutations that could be passed on from generation to generation — maybe even in humans — were on the list of concerns. It all seemed very far off back in the 70’s, but not anymore. According to WIRED writer Amy Maxmen,
“Crispr-Cas9 makes it easy, cheap, and fast to move genes around—any genes, in any living thing, from bacteria to people.”
Maxmen states that startups are launching with Crispr as their focus. Two quotes that I have used excessively come to mind. First, Tobias Revell: “Someone, somewhere in a lab is playing with your future.”1. Next, from a law professor at Washington University in St. Louis: “We don’t write laws to protect against impossible things, so when the impossible becomes possible, we shouldn’t be surprised that the law doesn’t protect against it…” 2.
And so, we play catch-up. From the WIRED article:
“It could at last allow genetics researchers to conjure everything anyone has ever worried they would—designer babies, invasive mutants, species-specific bioweapons, and a dozen other apocalyptic sci-fi tropes. It brings with it all-new rules for the practice of research in the life sciences. But no one knows what the rules are—or who will be the first to break them.”
The most disconcerting part of all this, to me, is that now, before the rules exist that even the smallest breach in protocol could unleash repercussions of Biblical proportions. Everything from killer mosquitoes and flying spiders, horrific mutations and pandemics are up for grabs.
We’re not even close to ready for this. Don’t tell me that it could eradicate AIDS or Huntington’s disease. That is the coat that is paraded out whenever a new technology peers its head over the horizon.
“Now, with less than $100, an ordinary arachnologist can snip the wing gene out of a spider embryo and see what happens when that spider matures.”
It is time to get the public involved in these issues whether through grass-roots efforts or persistence with their elected officials to spearhead some legislation.
“…straight-out editing of a human embryo sets off all sorts of alarms, both in terms of ethics and legality. It contravenes the policies of the US National Institutes of Health, and in spirit at least runs counter to the United Nations’ Universal Declaration on the Human Genome and Human Rights. (Of course, when the US government said it wouldn’t fund research on human embryonic stem cells, private entities raised millions of dollars to do it themselves.) Engineered humans are a ways off—but nobody thinks they’re science fiction anymore.”
Maxmen interviewed Harvard geneticist George Church. In a closer to the article,
“When I ask Church for his most nightmarish Crispr scenario, he mutters something about weapons and then stops short. He says he hopes to take the specifics of the idea, whatever it is, to his grave. But thousands of other scientists are working on Crispr. Not all of them will be as cautious. “You can’t stop science from progressing,” Jinek says. “Science is what it is.” He’s right. Science gives people power. And power is unpredictable.”
Who do you trust?