Tag Archives: Human Genome

The ultimate wild card.

 

One of the things that futurists do when they imagine what might happen down the road is to factor in the wild card. Short of the sports or movie references a wild card is defined by dictionary.com as: “… of, being, or including an unpredictable or unproven element, person, item, etc.” One might use this term to say, “Barring a wild card event like a meteor strike, global thermonuclear war, or a massive earthquake, we can expect Earth’s population to grow by (x) percent.”

The thing about wild card events is that they do happen. 9/11 could be considered a wild card. Chernobyl, Fukushima, and Katrina would also fall into this category. At the core, they are unpredictable, and their effects are widespread. There are think tanks that work on the probabilities of these occurrences and then play with scenarios for addressing them.

I’m not sure what to call something that would be entirely predictable but that we still choose to ignore. Here I will go with a quote:

“The depravity of man is at once the most empirically verifiable reality but at the same time the most intellectually resisted fact.”

― Malcolm Muggeridge

Some will discount this automatically because the depravity of man refers to the Christian theology that without God, our nature is hopeless. Or as Jeremiah would say, our heart is “deceitful and desperately wicked” (Jeremiah 17:9).

If you don’t believe in that, then maybe you are willing to accept a more secular notion that man can be desperately stupid. To me, humanity’s uncanny ability to foul things up is the recurring (not-so) wild card. It makes all new science as much a potential disaster as it might be a panacea. We don’t consider it often enough. If we look back through my previous blogs from Transhumanism to genetic design, this threat looms large. You can call me a pessimist if you want, but the video link below stands as a perfect example of my point. It is a compilation of all the nuclear tests, atmospheric, underground, and underwater, since 1945. Some of you might think that after a few tests and the big bombs during WWII we decided to keep a lid on the insanity. Nope.

If you can watch the whole thing without sinking into total depression and reaching for the Clorox, you’re stronger than I am. And, sadly it continues. We might ask how we have survived this long.

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Meddling with the primal forces of nature.

 

 

One of the more ominous articles of recent weeks came from WIRED magazine in an article about the proliferation of DNA editing. The story is rich with technical talk and it gets bogged down in places but essentially it is about a group of scientists who are concerned about the Pandora’s Box they may have created with something called Crispr-Cas9, or Crispr for short. Foreseeing this as far back as 1975, the group thought that establishing “guidelines” for what biologists could and could not do; things like creating pathogens and mutations that could be passed on from generation to generation — maybe even in humans — were on the list of concerns. It all seemed very far off back in the 70’s, but not anymore. According to WIRED writer Amy Maxmen,

“Crispr-Cas9 makes it easy, cheap, and fast to move genes around—any genes, in any living thing, from bacteria to people.”

Maxmen states that startups are launching with Crispr as their focus. Two quotes that I have used excessively come to mind. First, Tobias Revell: “Someone, somewhere in a lab is playing with your future.”1. Next, from a law professor at Washington University in St. Louis: “We don’t write laws to protect against impossible things, so when the impossible becomes possible, we shouldn’t be surprised that the law doesn’t protect against it…” 2.

And so, we play catch-up. From the WIRED article:

“It could at last allow genetics researchers to conjure everything anyone has ever worried they would—designer babies, invasive mutants, species-specific bioweapons, and a dozen other apocalyptic sci-fi tropes. It brings with it all-new rules for the practice of research in the life sciences. But no one knows what the rules are—or who will be the first to break them.”

The most disconcerting part of all this, to me, is that now, before the rules exist that even the smallest breach in protocol could unleash repercussions of Biblical proportions. Everything from killer mosquitoes and flying spiders, horrific mutations and pandemics are up for grabs.

We’re not even close to ready for this. Don’t tell me that it could eradicate AIDS or Huntington’s disease. That is the coat that is paraded out whenever a new technology peers its head over the horizon.

“Now, with less than $100, an ordinary arachnologist can snip the wing gene out of a spider embryo and see what happens when that spider matures.”

Splice-movie-baby-Dren
From the movie “Splice”. Sometimes bad movies can be the most prophetic.

It is time to get the public involved in these issues whether through grass-roots efforts or persistence with their elected officials to spearhead some legislation.

“…straight-out editing of a human embryo sets off all sorts of alarms, both in terms of ethics and legality. It contravenes the policies of the US National Institutes of Health, and in spirit at least runs counter to the United Nations’ Universal Declaration on the Human Genome and Human Rights. (Of course, when the US government said it wouldn’t fund research on human embryonic stem cells, private entities raised millions of dollars to do it themselves.) Engineered humans are a ways off—but nobody thinks they’re science fiction anymore.”

Maxmen interviewed Harvard geneticist George Church. In a closer to the article,

“When I ask Church for his most nightmarish Crispr scenario, he mutters something about weapons and then stops short. He says he hopes to take the specifics of the idea, whatever it is, to his grave. But thousands of other scientists are working on Crispr. Not all of them will be as cautious. “You can’t stop science from progressing,” Jinek says. “Science is what it is.” He’s right. Science gives people power. And power is unpredictable.”

Who do you trust?

 

 

1. Critical Exploits. Performed by Tobias Revell. YouTube. January 28, 2014. Accessed February 14, 2014. http://www.youtube.com/watch?v=jlpq9M1VELU#t=364.
2. Farivar, Cyrus. “DOJ Calls for Drone Privacy Policy 7 Years after FBI’s First Drone Launched.” Ars Technica. September 27, 2013. Accessed March 13, 2014. http://arstechnica.com/tech-policy/2013/09/doj-calls-for-drone-privacy-policy-7-years-after-fbis-first-drone-launched/.
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